Patterson signed a minor league contract with Los Angeles Dodgers affiliate the Albuquerque Dukes in late 1986 but never played at the major league level.In 1988, Patterson formed the Arclight Theatre Company in Soho, NYC with John Bishop.Like the majority of fans, the actor was sad to see the show, which left numerous ends untied, come to a close.[soundcloud url="https://api.soundcloud.com/tracks/295335285" params="visual=true&auto_play=false&hide_related=false&show_comments=true&show_user=true&show_reposts=false" width="100%" height="450" iframe="true" /] “Season 7 ended — we didn’t know it was the end of the series,” Patterson explained. I got the call in Toronto on a film set that summer that the show was cancelled.” Unfortunately, the series came to an end without its creator-writer Amy Sherman-Palladino — but the actor wasn’t surprised. I don’t know if I really felt that bad,” he said, and added, “I wasn’t terribly surprised.
He had a profound effect on Grace (Debra Messing) in the "Das Boob" episode of Will & Grace, and he played the love interests of Jennifer Grey in It's Like, You Know and Sharon Lawrence's character in Fired Up. Among Patterson's recent projects are a co-starring role on Aliens in America and voicing the character of King Faraday in the 2004 animated series Justice League Unlimited, from Warner Bros. He has also starred as Agent Strahm in two iterations of the Saw franchise, Saw IV and Saw V respectively, also appearing through flashback sequences in Saw VI.
Patterson was initially selected by the Atlanta Braves in the first round (12th overall) of the 1980 Major League Baseball draft.
He played his first pro season with their Class A Anderson Braves in 1980.
In 1981 Patterson won 13 consecutive games as a starting pitcher between Class A Durham and Double-A Savannah to set a Braves record for most consecutive wins to start a season.
He was named the Braves Minor League Pitcher of the month twice.