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HPV-associated cancers make up over 5% of total diagnosed cancer cases worldwide, and this incidence is higher in developing countries where it is estimated to cause almost half a million cases each year.

E6 produces a protein (also called E6) that binds to and inactivates a protein in the host cell called p53.Moreover, findings indicate this type of cancer is much more prevalent in men than in women, something that needs to be further explored.Some evidence links HPV to benign and malignant tumors of the upper respiratory tract.As with cutaneous HPVs, immunity to genital HPV is believed to be specific to a specific strain of HPV.In addition to genital warts, infection by HPV types 6 and 11 can cause a rare condition known as recurrent laryngeal papillomatosis, in which warts form on the larynx About a dozen HPV types (including types 16, 18, 31, and 45) are called "high-risk" types because persistent infection has been linked to cancers such as cancer of the oropharynx, larynx, vulva, vagina, cervix, penis, and anus.

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