In November 2007, Merck presented new data on Gardasil.In an investigational study, Gardasil reduced the incidence of HPV types 6, 11, 16 and 18-related persistent infection and disease in women through age 45.The panel's recommendation is intended to prevent genital warts and anal cancers in males, and possibly prevent head and neck cancer (though the vaccine's effectiveness against head and neck cancers has not yet been proven).In males, Gardasil may reduce their risk of genital warts and precancerous lesions caused by HPV.Gardasil has been shown to also be effective in preventing genital warts in males.While Gardasil and Gardasil-9 vaccines have been approved for males, the third HPV vaccine, Cervarix, is not administered to males.has reported that spokespersons for the Ministry of Health have said they’ve not yet received notice of the Constitutional Court’s ruling but noted that, despite the 2013 law, anyone who wishes to opt out of receiving the HPV vaccine may do so by requesting an exemption to the vaccine in writing. 4, 2017, a group known as the Colombian Rebuilding Hope Association filed a class action lawsuit against the Colombian government and Merck Sharp & Dohme on behalf of 700 people alleging they have been harmed by the Gardasil HPV vaccine.The lawsuit seeks compensation of approximately .5 million for “damage allegedly due to the vaccine, mainly symptoms that affect the immune and neurologic systems.” It also calls for a “declaration that the vaccine is unsafe.” There has been heightened concern about the HPV vaccine in Colombia since 2014 when more than 200 girls in the town of El Carmen de Bolivar in the northern part of the country were hospitalized after receiving the Gardasil vaccine.
HPV vaccines are approved for males in several countries, including Canada, Australia, South Korea, Hong Kong (SAR of China), the United Kingdom, New Zealand and the United States.
Since the vaccine only covers some high-risk types of HPV, cervical cancer screening is recommended even after vaccination.
In the US, the recommendation is for women to receive routine Pap smears beginning at age 21.
Unlike the Gardasil-based vaccines, Cervarix does not protect against genital warts.
On October 25, 2011, an advisory panel for the Centers for Disease Control and Prevention (CDC) voted to recommend that the vaccine should be given to boys ages 11–12.